Description

Penetratin CAS NO 214556-79-3 is a cell-penetrating peptide (CPP) derived from the Antennapedia homeodomain of Drosophila. This compound is essential for facilitating the intracellular delivery of a wide range of cargo molecules, including drugs, proteins, and nucleic acids, overcoming a major barrier in therapeutic and research applications. It is a critical tool for researchers and developers in the pharmaceutical, biotechnology, and life sciences industries seeking to enhance cellular uptake and bioavailability of bioactive compounds.

Application

• Drug Delivery Vector: Used to enhance the cellular internalization of therapeutic agents, including anticancer drugs and oligonucleotides.
• Research Reagent: Employed in molecular and cellular biology studies to introduce impermeable molecules into cells for functional analysis.
• Cosmeceutical Ingredient: Incorporated in topical formulations to improve skin penetration and efficacy of active ingredients like peptides and antioxidants.
• Diagnostic Agent Carrier: Facilitates the delivery of imaging probes and contrast agents into cells for diagnostic purposes.
• Gene Therapy: Acts as a non-viral vector component to assist in the transfection and delivery of plasmid DNA or siRNA.
• Protein Transduction: Enables the study of protein function by mediating the uptake of full-length proteins or functional domains into living cells.

Basic Information

Product Name	Penetratin
CAS No.	214556-79-3
Molecular Formula	C₁₀₀H₁₅₉N₃₉O₂₈
Molecular Weight	2246.6 g/mol
Synonyms	Penetratin peptide; Antennapedia (43-58) peptide; Antp homeodomain-derived peptide; pAntp(43-58); RQIKIWFQNRRMKWKK; Cell-penetrating peptide penetratin; AntpHD CPP; Drosophila Antennapedia homeobox peptide fragment
EINECS	Contact for details

Quality Control

Our Penetratin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are provided to ensure compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the material desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Composition	Conforms to theoretical values
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.