Description

(R)-(+)-Nbeta-Boc-D-Hydrazinoproline CAS NO 214262-81-4 is a high-purity, non-natural amino acid derivative featuring a protected hydrazino group and a Boc-protected secondary amine. This compound is a critical chiral building block for the synthesis of complex molecules, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including protease inhibitors and peptide-based drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce hydrazino-proline motifs, which can be further functionalized.
• Chemical Biology Probes: Serves as a building block for creating labeled peptides and probes to study enzyme mechanisms and protein-protein interactions.
• Ligand Development: Employed in the design and synthesis of novel ligands for asymmetric catalysis and medicinal chemistry applications.
• Academic & Industrial Research: A valuable reagent for methodological development in organic synthesis and for exploring new chemical space in drug discovery programs.

Basic Information

Product Name	(R)-(+)-Nbeta-Boc-D-Hydrazinoproline
CAS No.	214262-81-4
Molecular Formula	C10H19N3O4
Molecular Weight	245.28 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)-2-hydrazinylpyrrolidine-2-carboxylic Acid; (R)-Nβ-Boc-D-Hydrazinoproline; (2R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-2-hydrazinylpyrrolidine-2-carboxylic Acid; Boc-D-Hyp(NHNH2)-OH; (R)-(+)-N-Boc-D-Hydrazinoproline; tert-Butyl (2R)-2-hydrazinyl-2-carboxypyrrolidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our (R)-(+)-Nbeta-Boc-D-Hydrazinoproline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral assay, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to maintain stability. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.