Description

(3Ar,8Ar)-(-)-(2,2-Dimethyl-4,4,8,8-Tetraphenyl-Tetrahydro-[1,3]Dioxolo[4,5-E][1,3,2]Dioxaphosphepin-6-Yl)Dimethylamine is a sophisticated chiral organophosphorus compound, specifically a P-stereogenic phosphite-amine ligand. This compound matters as a highly effective chiral ligand and catalyst precursor in asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for critical asymmetric hydrogenation and C-C bond formation reactions.

Application

• Asymmetric Hydrogenation Catalyst Ligand: For the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Asymmetric C-C Bond Formation: As a chiral ligand in Rhodium or Iridium-catalyzed reactions like allylic alkylation and hydroformylation.
• Chiral Auxiliary Synthesis: Serving as a building block for constructing other complex, P-stereogenic ligands and catalysts.
• Pharmaceutical Process Development: Enabling the scalable, cost-effective production of single-enantiomer active pharmaceutical ingredients (APIs).
• Agrochemical Intermediate Synthesis: For creating chiral herbicides, fungicides, and plant growth regulators.
• Academic & Industrial Research: A valuable tool for methodology development in stereoselective organic synthesis.

Basic Information

Item	Detail
Product Name	(3Ar,8Ar)-(-)-(2,2-Dimethyl-4,4,8,8-Tetraphenyl-Tetrahydro-[1,3]Dioxolo[4,5-E][1,3,2]Dioxaphosphepin-6-Yl)Dimethylamine
CAS No.	213843-90-4
Molecular Formula	C35H36NO4P
Molecular Weight	565.64 g/mol
Synonyms	(-)-2,2-Dimethyl-4,4,8,8-tetraphenyl-1,3,2λ⁵-dioxa[4,5-e][1,3,2]dioxaphosphepin-6-yl dimethylamine; (3aR,8aR)-(-)-2,2-Dimethyl-4,4,8,8-tetraphenyltetrahydro-1,3,2λ⁵-dioxa[4,5-e][1,3,2]dioxaphosphepin-6-yl dimethylamine; P-Phos type ligand; Chiral phosphite-amine ligand; (R,R)-(-)-P-Phos; (3aR,8aR)-(-)-P-Phos; (R,R)-(-)-2,2-Dimethyl-α,α,α',α'-tetraphenyl-1,3-dioxolane-4,5-dimethanol cyclic phosphoramidite
EINECS	Contact for details

Quality Control

Our (3Ar,8Ar)-(-)-(2,2-Dimethyl-4,4,8,8-Tetraphenyl-Tetrahydro-[1,3]Dioxolo[4,5-E][1,3,2]Dioxaphosphepin-6-Yl)Dimethylamine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chiral purity. Each lot undergoes comprehensive analytical characterization, including HPLC for chemical purity and chiral purity (enantiomeric excess), alongside NMR and MS for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.