Description

2-Dicyclohexylphosphino-2'-(N,N-Dimethylamino)biphenyl is a specialized, air-sensitive organophosphorus ligand widely recognized for its efficacy in transition metal catalysis. Its primary value lies in enabling highly efficient and selective cross-coupling reactions, which are fundamental to modern synthetic chemistry. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-performance catalysts for complex molecule synthesis. The CAS number for this compound is provided in the table below.

Application

This versatile ligand finds critical use in a variety of catalytic transformations:

• Buchwald-Hartwig Amination: A key catalyst component for the efficient coupling of amines with aryl halides, crucial for constructing C-N bonds in drug discovery.
• Suzuki-Miyaura Cross-Coupling: Facilitates the formation of C-C bonds between aryl/vinyl boronic acids and halides, a cornerstone reaction in medicinal and materials chemistry.
• Negishi and Kumada Couplings: Enables reactions with organozinc and organomagnesium reagents for diverse carbon-carbon bond formations.
• Pharmaceutical Intermediate Synthesis: Used in the scalable production of active pharmaceutical ingredients (APIs) and complex heterocycles.
• Agrochemical Manufacturing: Applied in the synthesis of novel herbicides, fungicides, and insecticides requiring selective coupling steps.
• Academic & Industrial R&D: Serves as a fundamental tool for developing new catalytic methodologies and exploring novel chemical space.
• Polymer and OLED Material Synthesis: Aids in creating conjugated polymers and organic light-emitting diode (OLED) precursors via precise coupling reactions.

Basic Information

Product Name	2-Dicyclohexylphosphino-2'-(N,N-Dimethylamino)biphenyl
CAS No.	213697-53-1
Molecular Formula	C26H36NP
Molecular Weight	393.55 g/mol
Synonyms	DavePhos; 2-(Dicyclohexylphosphino)-2'-(N,N-dimethylamino)biphenyl; 2-(Dicyclohexylphosphino)-N,N-dimethyl-2'-aminobiphenyl; 2'-(Dimethylamino)-2-dicyclohexylphosphinobiphenyl; 2-Dicyclohexylphosphino-2'-dimethylaminobiphenyl; Dicyclohexyl(2'-dimethylamino[1,1'-biphenyl]-2-yl)phosphine; [2'-(Dimethylamino)-[1,1'-biphenyl]-2-yl]dicyclohexylphosphine
EINECS	Contact for details

Quality Control

Our production of 2-Dicyclohexylphosphino-2'-(N,N-Dimethylamino)biphenyl adheres to stringent quality protocols to ensure batch-to-batch consistency and performance. Each lot undergoes comprehensive analytical characterization, including NMR (¹H, ³¹P) and HPLC analysis, to verify identity and purity. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxygen, this material should be stored under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C). Keep the container tightly sealed in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
³¹P NMR Purity	Conforms
Solubility Test	Freely soluble in common organic solvents (THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.