Description

Boc-Gln[Trt]-Ol is a protected amino acid derivative widely used as a critical building block in solid-phase peptide synthesis (SPPS). This compound is essential for researchers and manufacturers requiring high-purity intermediates to construct complex peptides with specific sequences. It is primarily utilized in pharmaceutical R&D, biotechnology, and academic laboratories for the production of therapeutic peptides, peptide hormones, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential addition of glutamine residues during automated or manual peptide chain assembly.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including potential treatments for metabolic disorders, cancer, and infectious diseases.
• Bioconjugation and Probe Development: Serves as a modified amino acid precursor for creating labeled peptides used in diagnostic assays and imaging studies.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Institutional Research: A fundamental reagent for studying protein-protein interactions, enzyme substrates, and peptide structure-activity relationships (SAR).
• Custom Peptide Service Providers: A staple raw material for CROs and CDMOs offering bespoke peptide synthesis services to the biotech and pharma industries.

Basic Information

Product Name	Boc-Gln[Trt]-Ol
CAS No.	213488-16-5
Molecular Formula	C29H32N2O4
Molecular Weight	472.58 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-N-δ-trityl-L-glutamine; Boc-L-glutamine(Tr)-OH; Boc-Gln(Trt)-OH; (2S)-5-Oxo-2-[[(2-methylpropan-2-yl)oxycarbonylamino]-5-(tritylamino)pentanoic acid; tert-Butoxycarbonyl-glutamine(trityl); N-Boc-N'-trityl-L-glutamine; Boc-Glutamine(Trt)-OH; Fmoc-Gln(Trt)-OH precursor
EINECS	Contact for details

Quality Control

Every batch of Boc-Gln[Trt]-Ol is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay, chiral purity, and related substances. Our quality commitment aligns with the standards expected for pharmaceutical intermediates and fine chemicals used in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry atmosphere to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-15.0° to -18.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.