Description

3-(Trifluoromethylthio)Benzyl Bromide is a versatile and high-value organobromide building block characterized by the presence of both a reactive benzyl bromide group and a stable, lipophilic trifluoromethylthio (SCF₃) moiety. This compound matters for its critical role in the synthesis of advanced pharmaceutical intermediates and agrochemicals, where the SCF₃ group is prized for its ability to modulate the metabolic stability, lipophilicity, and bioavailability of target molecules. Chemical manufacturers and R&D laboratories in the pharmaceutical, agrochemical, and material science sectors need this high-purity intermediate to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for introducing the trifluoromethylthio group into bioactive molecules, enhancing their drug-like properties for new therapeutic candidates.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the SCF₃ group improves efficacy and environmental profile.
• Material Science: Serves as a precursor for functionalized monomers or ligands used in specialty polymers, coatings, and advanced materials.
• Chemical Research & Development: An essential building block for medicinal chemistry and process chemistry research in both academic and industrial settings.
• Ligand and Catalyst Preparation: Can be utilized to synthesize novel ligands or organocatalysts containing the SCF₃ functionality.
• Fluorine Chemistry: A valuable reagent for expanding the toolbox of fluorine-containing compounds available for discovery programs.

Basic Information

Product Name	3-(Trifluoromethylthio)Benzyl Bromide
CAS No.	213203-84-0
Molecular Formula	C₈H₆BrF₃S
Molecular Weight	271.10 g/mol
Synonyms	α-Bromo-3-[(trifluoromethyl)thio]toluene; 1-(Bromomethyl)-3-[(trifluoromethyl)thio]benzene; 3-(Trifluoromethylthio)benzyl bromide; (3-((Trifluoromethyl)thio)phenyl)methyl bromide; m-(Trifluoromethylthio)benzyl bromide; 3-(SCF3)Benzyl Bromide; 3-Trifluoromethylthiobenzyl Bromide
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethylthio)Benzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistent quality suitable for sensitive synthesis applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.