Description

Fmoc-D-β-Homoleucine CAS NO 212688-54-5 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is a critical building block for the development of novel peptide-based pharmaceuticals and research tools, offering precise stereochemical control. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the production of complex peptides, peptidomimetics, and bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled assembly of complex peptide chains.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of new therapeutic peptides targeting various diseases.
• Peptidomimetic Design: Incorporation of the D-β-homoleucine side chain introduces unique conformational and steric properties to mimic natural peptide structures.
• Bioconjugation and Labeling: Serves as a modified amino acid handle for attaching fluorophores, tags, or other functional groups to peptides.
• Combinatorial Chemistry Libraries: A valuable component for creating diverse libraries of peptide analogs for high-throughput screening.
• Academic and Industrial Research: Fundamental research tool in biochemistry, medicinal chemistry, and chemical biology for studying protein-protein interactions and enzyme activity.

Basic Information

Product Name	Fmoc-D-β-Homoleucine
CAS No.	212688-54-5
Molecular Formula	C22H25NO5
Molecular Weight	383.44 g/mol
Synonyms	Fmoc-D-β-Homoleucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-β-homoleucine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-methylhexanoic acid; Fmoc-D-β-hLeu-OH; Fmoc-D-β-homo-Leucine; N-Fmoc-D-β-homoleucine; Fmoc-D-β-Hle-OH
EINECS	Contact for details

Quality Control

Our Fmoc-D-β-Homoleucine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.