Description

Fmoc-3,5-Diiodo-D-Tyrosine is a protected, non-natural amino acid derivative of significant importance in peptide synthesis. This compound is specifically engineered for the solid-phase synthesis of complex peptides, offering enhanced stability and controlled reactivity. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing peptide-based therapeutics, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of peptides containing iodinated tyrosine residues.
• Pharmaceutical Research: Used in the development of novel peptide drugs, hormone analogs, and targeted therapeutics.
• Radiopharmaceuticals: Serves as a precursor for the synthesis of iodine-123 or iodine-131 labeled peptides for diagnostic imaging and radiotherapy.
• Bioconjugation: Enables the site-specific incorporation of iodine atoms into peptides for subsequent labeling or cross-linking studies.
• Chemical Biology: A valuable tool for probing protein structure-function relationships and studying protein-protein interactions.
• Material Science: Can be used to create specialized peptide-based polymers and biomaterials with unique properties.

Basic Information

Product Name	Fmoc-3,5-Diiodo-D-Tyrosine
CAS No.	212651-51-9
Molecular Formula	C24H19I2NO5
Molecular Weight	703.22 g/mol
Synonyms	Fmoc-D-Tyr(3,5-I2)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,5-diiodo-D-tyrosine; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(3,5-diiodo-4-hydroxyphenyl)propanoic acid; Fmoc-3,5-diiodotyrosine(D); Fmoc-D-3,5-Diiodotyrosine; N-Fmoc-3,5-diiodo-D-tyrosine; Fmoc-Tyr(3,5-I2)-OH (D-form)
EINECS	Contact for details

Quality Control

Our Fmoc-3,5-Diiodo-D-Tyrosine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide Certificates of Analysis (COA) with detailed specifications for trace solvents, heavy metals, and other critical impurities, ensuring compliance with research and cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.