Description

Fmoc-Sarcosine Hydrate CAS NO 212651-47-3 is a protected amino acid derivative where the sarcosine (N-methylglycine) amine group is safeguarded by a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptides. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the automated or manual synthesis of custom peptides and peptidomimetics.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide-based therapeutics, including hormones, antibiotics, and targeted drug conjugates.
• Bioconjugation: Serves as a linker or spacer molecule in the chemical modification of proteins, antibodies, and other biomolecules.
• Combinatorial Chemistry: A key reagent in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Industrial Research: Employed in biochemical studies to investigate protein structure-function relationships and enzyme mechanisms.
• Production of Modified Peptides: Specifically introduces an N-methylated amide bond into peptide chains, which can enhance metabolic stability and membrane permeability.

Basic Information

Product Name	Fmoc-Sarcosine Hydrate
CAS No.	212651-47-3
Molecular Formula	C18H17NO4 • xH2O
Molecular Weight	311.33 g/mol (Anhydrous basis)
Synonyms	Fmoc-Sar-OH Hydrate; N-(9-Fluorenylmethoxycarbonyl)-N-methylglycine Hydrate; N-Fmoc-N-methylglycine Hydrate; (9H-Fluoren-9-yl)methyl (methylcarbamoyl)acetate Hydrate; Fmoc-N-methylglycine Hydrate; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]sarcosine Hydrate; Fmoc-Sarcosine Monohydrate (typical form)
EINECS	Contact for details

Quality Control

Our Fmoc-Sarcosine Hydrate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive applications like peptide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific research or cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent hydration level variation and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0% (Anhydrous basis)
Water Content (KF)	3.0% - 8.0%
Specific Rotation	Contact for details
Heavy Metals	<10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.