Description

(3Ar,8As)-2-[2-(Diphenylphosphino)Phenyl]-3A,8A-Dihydro-8H-Indeno[1,2-D]Oxazole CAS NO 212312-33-9 is a sophisticated chiral P,N-ligand, a critical component in asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, enabling the production of single-enantiomer compounds with superior purity and efficacy. This product is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for synthesizing advanced intermediates and active ingredients.

Application

• As a privileged ligand for asymmetric hydrogenation of olefins, ketones, and imines in pharmaceutical synthesis.
• Key component in rhodium- or iridium-catalyzed enantioselective reactions for creating chiral building blocks.
• Utilized in the development of novel catalytic processes for the production of agrochemicals and flavors/fragrances.
• Critical for academic and industrial R&D in homogeneous catalysis to explore new reaction pathways.
• Enables C-C and C-X bond-forming reactions with high stereoselectivity for complex molecule assembly.
• Used in the synthesis of single-enantiomer active pharmaceutical ingredients (APIs) to meet stringent regulatory requirements.

Basic Information

Item	Detail
Product Name	(3Ar,8As)-2-[2-(Diphenylphosphino)Phenyl]-3A,8A-Dihydro-8H-Indeno[1,2-D]Oxazole
CAS No.	212312-33-9
Molecular Formula	C28H22NOP
Molecular Weight	419.46 g/mol
Synonyms	Indenyl-oxazoline phosphine ligand; (R)-2-[2-(Diphenylphosphino)phenyl]-4,5-dihydro-3aH-cyclopenta[b]oxazole; (R)-2-[2-(Diphenylphosphino)phenyl]-4,5-dihydro-3aH-indeno[1,2-d]oxazole; (R)-IndaBOX-Ph; (R)-IndaBoxPh; (R)-2-[2-(Diphenylphosphino)phenyl]-3a,8a-dihydro-8H-indeno[1,2-d]oxazole; (3aR,8aR)-2-[2-(Diphenylphosphino)phenyl]-3a,8a-dihydro-8H-indeno[1,2-d]oxazole
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality management to ensure consistency and performance in catalytic applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, enantiomeric excess, and identity confirmation. Our quality systems support compliance with cGMP standards for advanced pharmaceutical intermediates, ensuring traceability and reliability for critical process development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry place. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain catalytic activity and purity.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.