Description

Sumatriptan n-Oxide is a key pharmaceutical intermediate and metabolite of the widely used migraine medication, Sumatriptan. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of related active pharmaceutical ingredients (APIs). It serves as a critical reference standard and building block for analytical laboratories, contract research organizations (CROs), and manufacturers focused on neurology and central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of Sumatriptan metabolites in bioanalytical studies and method validation.
• Drug Metabolism & Pharmacokinetics (DMPK) Research: Essential for investigating the metabolic pathways, bioavailability, and excretion profiles of Sumatriptan in preclinical and clinical research.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a sophisticated intermediate or precursor in the multi-step synthesis of Sumatriptan and its structural analogs.
• Analytical Method Development: Critical for developing and calibrating high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), and other analytical techniques in quality control labs.
• Impurity Profiling: Employed to identify, characterize, and control process-related impurities and degradation products in Sumatriptan drug substance and finished dosage forms.
• Regulatory Compliance & Documentation: Supports regulatory filings (e.g., with FDA, EMA) by providing definitive characterization data for drug substances as part of Investigational New Drug (IND) and New Drug Application (NDA) dossiers.

Basic Information

Product Name	Sumatriptan n-Oxide
CAS No.	212069-94-8
Molecular Formula	C14H21N3O2S
Molecular Weight	295.40 g/mol
Synonyms	1-[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]-N-methyl-methanesulfonamide N-Oxide; Sumatriptan Impurity F (EP); Sumatriptan N-Oxide Impurity; Sumatriptan Related Compound F; GR 43175 N-Oxide; 3-[2-(Dimethylamino)ethyl]-5-[(methylsulfonylamino)methyl]-1H-indole 1-Oxide
EINECS	Contact for details

Quality Control

Our Sumatriptan n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for every lot to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15°C and 25°C (59°F and 77°F), in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.