Description

2(3H)-Furanone,3,3-Difluorodihydro-5-(Hydroxymethyl)-,(5R)-(9Ci) is a high-value, chiral fluorinated lactone building block of significant interest in advanced organic synthesis. Its unique structure, featuring a difluorinated lactone core and a hydroxymethyl group in a specific stereochemical configuration, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its fluorine atoms can enhance metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new Active Pharmaceutical Ingredients (APIs), particularly in areas targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the difluoromethylene group can improve lipophilicity and environmental stability.
• Fluorine Chemistry Research: Serves as a valuable substrate for studying novel fluorination reactions and the stereoselective introduction of fluorine-containing motifs into complex molecular architectures.
• Material Science Precursor: Potential use in the synthesis of specialty polymers and liquid crystals, where fluorinated units impart unique thermal, chemical, and surface properties.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of fluorinated target molecules.

Basic Information

Product Name	2(3H)-Furanone,3,3-Difluorodihydro-5-(Hydroxymethyl)-,(5R)-(9Ci)
CAS No.	211807-33-9
Molecular Formula	C5H6F2O3
Molecular Weight	152.10 g/mol
Synonyms	(5R)-3,3-Difluoro-5-(hydroxymethyl)dihydrofuran-2(3H)-one; (5R)-3,3-Difluoro-5-(hydroxymethyl)-2(3H)-furanone; 3,3-Difluoro-5-(hydroxymethyl)dihydro-2(3H)-furanone, (5R)-; (R)-3,3-Difluoro-5-(hydroxymethyl)dihydrofuran-2(3H)-one; 2(3H)-Furanone, dihydro-3,3-difluoro-5-(hydroxymethyl)-, (5R)-; Fluorinated lactone intermediate 211807-33-9
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols. Each batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure high chemical and enantiomeric purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.