Description

1-Propyn-1-Amine,3,3,3-Trifluoro-N,n-Dimethyl-(9Ci) is a specialized trifluoromethylated propargyl amine derivative, a high-value building block in advanced organic synthesis. Its core value lies in introducing the trifluoromethyl group and a reactive alkyne moiety, enabling the construction of complex molecules with enhanced metabolic stability and lipophilicity. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for applications requiring fluorine chemistry.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in kinase inhibitors, CNS-active compounds, and anti-infective agents where the trifluoromethyl group improves bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms contribute to weather resistance and biological activity.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, or advanced coatings that benefit from fluorine's unique properties like chemical resistance and low surface energy.
• Click Chemistry: The terminal alkyne group makes it a valuable substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, facilitating the rapid assembly of molecular libraries for screening.
• Fluorine Chemistry & Catalysis: Employed in methodological studies to develop new fluorination reactions or as a ligand precursor in catalytic systems.
• Diagnostic Agent Development: Potential use in synthesizing radiolabeled probes or contrast agents for imaging technologies like PET (Positron Emission Tomography).

Basic Information

Product Name	1-Propyn-1-Amine,3,3,3-Trifluoro-N,n-Dimethyl-(9Ci)
CAS No.	211803-07-5
Molecular Formula	C5H6F3N
Molecular Weight	137.10 g/mol
Synonyms	3,3,3-Trifluoro-N,N-dimethylprop-2-yn-1-amine; N,N-Dimethyl-3,3,3-trifluoroprop-2-yn-1-amine; 3,3,3-Trifluoropropyne, 1-(dimethylamino)-; 1-(Dimethylamino)-3,3,3-trifluoropropyne; N,N-Dimethyl-3,3,3-trifluoro-1-propynylamine; 3,3,3-Trifluoro-N,N-dimethyl-1-propynylamine; Trifluoromethylated propargyl amine; (3,3,3-Trifluoroprop-1-yn-1-yl)dimethylamine
EINECS	Contact for details

Quality Control

Our 1-Propyn-1-Amine,3,3,3-Trifluoro-N,n-Dimethyl-(9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data including HPLC purity, GC analysis, and NMR spectroscopy for identity confirmation. A detailed Certificate of Analysis (COA) is supplied with each batch, and custom purity grades or analytical packages can be discussed to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95% (Standard Grade)
Water Content (KF)	≤ 0.5%
NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.