Description

Fmoc-L-3-Methylphe CAS NO 211637-74-0 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the controlled and efficient assembly of complex peptides and peptidomimetics. It is primarily required by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the sequential construction of custom peptide sequences in automated synthesizers.
• Pharmaceutical Research & Development: Used in the discovery and development of peptide-based drugs, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Bioconjugation & Probe Synthesis: Enables the site-specific incorporation of non-natural amino acids into peptides for labeling, imaging, or creating peptide-drug conjugates.
• Combinatorial Chemistry Libraries: A key component in generating diverse libraries of peptide compounds for high-throughput screening against biological targets.
• Academic & Biochemical Research: Employed in studies of protein structure-function relationships, enzyme-substrate interactions, and signal transduction pathways.
• Production of Peptide Fragments: Used for the synthesis of specific peptide fragments required for antibody production (antigens) or structural biology studies like crystallography.

Basic Information

Item	Details
Product Name	Fmoc-L-3-Methylphe
CAS No.	211637-74-0
Molecular Formula	C25H23NO4
Molecular Weight	401.46 g/mol
Synonyms	Fmoc-3-methyl-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methyl-L-phenylalanine; Fmoc-3-Me-Phe-OH; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(3-methylphenyl)propanoic acid; Fmoc-L-β-(3-methylphenyl)alanine; N-Fmoc-3-methyl-L-phenylalanine; Fmoc-3-methylphenylalanine; Fmoc-L-3-methylphenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-L-3-Methylphe is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via NMR and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research and cGMP-grade standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.