Description

3-n-Carboxylic Acid 1-β-D-Glucuronide-[4-(Methyl)Phenyl]Carbamate Ester Doxorubicin is a sophisticated, targeted prodrug derivative of the potent anthracycline chemotherapeutic agent, doxorubicin. This compound is engineered for enhanced specificity and reduced systemic toxicity by leveraging a glucuronide-carbamate linker system for selective activation. It is a critical intermediate and research material for the development of advanced antibody-drug conjugates (ADCs) and targeted cancer therapies. Pharmaceutical R&D laboratories and advanced manufacturers in the oncology sector require this high-purity chemical for developing next-generation treatments.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as a key cytotoxic warhead or intermediate in the synthesis of novel ADC constructs designed for targeted cancer cell delivery.
• Prodrug Development: Used in research to create enzyme-activated prodrugs, particularly for therapies targeting tumors with high β-glucuronidase activity.
• Oncology Research: A vital reference standard and active pharmaceutical ingredient (API) intermediate in preclinical and clinical studies for novel chemotherapeutic agents.
• Chemical Biology Studies: Employed to investigate drug release mechanisms, linker stability, and the structure-activity relationships of modified anthracyclines.
• Pharmaceutical Synthesis: Acts as a advanced building block for the chemical synthesis of more complex, targeted doxorubicin derivatives.

Basic Information

Product Name	3-n-Carboxylic Acid 1-β-D-Glucuronide-[4-(Methyl)Phenyl]Carbamate Ester Doxorubicin
CAS No.	211364-63-5
Molecular Formula	C41H45NO19
Molecular Weight	855.80 g/mol
Synonyms	Doxorubicin glucuronide carbamate prodrug; Doxorubicin-1-β-D-glucuronide-4-methylphenyl carbamate; 1-β-D-Glucuronide-4-methylphenyl carbamate ester of Doxorubicin; Doxorubicin prodrug with glucuronide linker; (3'-N-Carboxypropionyl)doxorubicin-14-O-[1-β-D-glucuronyl-4-(methyl)phenyl] carbamate; Targeted doxorubicin derivative; ADC payload intermediate; Glucuronide-activated doxorubicin
EINECS	Contact for details

Quality Control

Our 3-n-Carboxylic Acid 1-β-D-Glucuronide-[4-(Methyl)Phenyl]Carbamate Ester Doxorubicin is manufactured under strict quality systems suitable for pharmaceutical research and development. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing batch-specific results. Our quality commitment aligns with cGMP principles for API intermediates, ensuring consistency and reliability for critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be sealed under an inert atmosphere after opening and allowed to equilibrate to room temperature before opening to prevent condensation. For long-term storage, maintain under argon or nitrogen atmosphere.

Specification

Item	Specification
Appearance	Red to orange-red solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.