Description

n-(8-Maleimidocapryloxy)Sulfosuccinimide, Sodium Salt is a heterobifunctional crosslinking reagent featuring a maleimide group and a sulfosuccinimidyl ester, designed for efficient and stable conjugation under aqueous conditions. This compound is engineered to facilitate the site-specific labeling of thiol-containing biomolecules, such as antibodies and proteins, with amine-containing probes, offering superior control and reduced aggregation. It is an essential tool for researchers and manufacturers in bioconjugation, diagnostic assay development, and ADC (Antibody-Drug Conjugate) linker chemistry.

Application

• Bioconjugation and Protein Labeling: For creating stable thioether linkages between thiols (e.g., on reduced antibodies or cysteine-engineered proteins) and amine-containing molecules like fluorescent dyes, enzymes, or drugs.
• Antibody-Drug Conjugate (ADC) Synthesis: Serves as a key heterobifunctional linker to connect cytotoxic payloads to monoclonal antibodies, enabling targeted cancer therapies.
• Diagnostic Reagent Development: Used to conjugate detection enzymes (e.g., HRP, alkaline phosphatase) or other labels to antibodies for ELISA, lateral flow assays, and other immunoassays.
• Surface Immobilization: Functionalizing solid supports (e.g., beads, chips, plates) with maleimide groups for the oriented capture of thiolated biomolecules.
• Polymer and Biomaterial Modification: Introducing reactive maleimide handles onto polymers or hydrogels for subsequent coupling with peptides or proteins.
• Peptide and Small Molecule Conjugation: Linking synthetic peptides or other amine-containing small molecules to carrier proteins or other thiolated entities.

Basic Information

Product Name	n-(8-Maleimidocapryloxy)Sulfosuccinimide, Sodium Salt
CAS No.	211236-35-0
Molecular Formula	C17H23N2NaO10S
Molecular Weight	470.43 g/mol
Synonyms	Sulfo-EMCS; Sodium 8-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-8-oxooctyl 3-[(2,5-Dioxo-1H-pyrrol-1-yl)oxy]-3-oxo-1-propanesulfonate; EMCS Sulfosuccinimidyl Ester; Maleimidocaproyloxysulfosuccinimide Sodium Salt; 8-Maleimidocaprylic Acid Sulfosuccinimidyl Ester Sodium Salt; Sulfo-N-succinimidyl 8-maleimidocaprylate; 1-[8-[[3-[(2,5-Dioxo-1-pyrrolyl)oxy]-3-oxopropyl]sulfonyl]oxy]-8-oxooctyl]-2,5-pyrrolidinedione Sodium Salt
EINECS	Contact for details

Quality Control

Our n-(8-Maleimidocapryloxy)Sulfosuccinimide, Sodium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.