Description

Abz-Arg-Val-Nle-p-Nitro-Phe-Glu-Ala-Nle-Nh2 is a synthetic, fluorogenic peptide substrate designed for high-sensitivity enzymatic assays. Its core value lies in its ability to provide a quantifiable fluorescent signal upon cleavage, making it an essential tool for precise kinetic studies and inhibitor screening. This compound is primarily needed by researchers and quality control laboratories in the pharmaceutical, biotechnology, and diagnostic sectors for studying protease activity, particularly for enzymes like furin and related proprotein convertases.

Application

• Protease Activity Assays: Used as a selective fluorogenic substrate for monitoring the enzymatic activity of furin and other proprotein convertases in real-time.
• Drug Discovery & High-Throughput Screening (HTS): Enables the rapid identification and characterization of protease inhibitors in pharmaceutical research.
• Biochemical Research: Serves as a critical reagent for studying enzyme kinetics, specificity, and catalytic mechanisms in academic and industrial R&D.
• Diagnostic Development: Potential use in developing clinical assays to measure specific protease levels associated with diseases like cancer and infectious diseases.
• Quality Control in Biologics: Employed in QC labs to ensure the consistency and activity of enzyme-based therapeutics and manufacturing processes.

Basic Information

Product Name	Abz-Arg-Val-Nle-p-Nitro-Phe-Glu-Ala-Nle-Nh2
CAS No.	210644-49-8
Molecular Formula	C58H84N16O16
Molecular Weight	1269.4 g/mol
Synonyms	Abz-RVK(p-NO2)EANle-NH2; o-Aminobenzoic acid-Arg-Val-Lys(p-Nitro-Phe)-Glu-Ala-Nle-amide; Furin Fluorogenic Substrate; Fluorogenic Peptide Substrate for Furin; Abz-RVKR-MCA Analog; p-Nitro-Phe containing Fluorogenic Peptide; PC Substrate; Proprotein Convertase Substrate
EINECS	Contact for details

Quality Control

Our Abz-Arg-Val-Nle-p-Nitro-Phe-Glu-Ala-Nle-Nh2 is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and MS for identity confirmation, to ensure it meets the high standards required for research and diagnostic applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 70%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.