Description

3,4-Difluorophenylacetic Acid Methyl Ester is a high-purity fluorinated aromatic ester building block. This compound is a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, valued for its ability to introduce the metabolically stable difluorophenyl moiety into target molecules. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key synthon for the production of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, anti-inflammatory drugs, and central nervous system (CNS) agents.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides where the difluorophenyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Used in the research and development of fluorinated organic electronic materials for displays and lighting.
• Advanced Polymer Monomers: Serves as a precursor for specialty polymers with unique thermal and chemical resistance properties.
• Chemical Research & Development: A versatile reagent in academic and industrial labs for exploring new fluorination chemistry and constructing complex molecular architectures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the scale-up and production of client-specific fine chemicals and target molecules.

Basic Information

Product Name	3,4-Difluorophenylacetic Acid Methyl Ester
CAS No.	210530-71-5
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	Methyl 2-(3,4-difluorophenyl)acetate; 2-(3,4-Difluorophenyl)acetic acid methyl ester; Methyl (3,4-difluorophenyl)acetate; 3,4-Difluorobenzeneacetic acid methyl ester; 210530-71-5; Methyl 3,4-difluorophenylacetate; 3,4-DFPA methyl ester
EINECS	Contact for details

Quality Control

Our 3,4-Difluorophenylacetic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting cGMP and ISO standards for traceability and reliability in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.