Description

(3,5-Difluoro-Phenyl)-Acetic Acid Methyl Ester is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the difluorophenyl moiety is crucial for modulating biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the fluorine atoms enhance lipophilicity and target binding.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated aromatic cores in electronic and display materials, improving thermal stability and optical properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Functional Material Research: Employed in academic and industrial R&D for developing novel polymers, ligands, and specialty chemicals with tailored properties.

Basic Information

Product Name	(3,5-Difluoro-Phenyl)-Acetic Acid Methyl Ester
CAS No.	210530-70-4
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	Methyl (3,5-difluorophenyl)acetate; (3,5-Difluorophenyl)acetic acid methyl ester; 2-(3,5-Difluorophenyl)acetic acid methyl ester; Methyl 2-(3,5-difluorophenyl)acetate; 3,5-Difluorobenzeneacetic acid methyl ester; 210530-70-4; (3,5-Difluorophenyl)acetate methyl ester
EINECS	Contact for details

Quality Control

Our (3,5-Difluoro-Phenyl)-Acetic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.