Description

Z-D-Asp(Otbu)-OH, H2O is a protected aspartic acid derivative, specifically the tert-butyl ester of Z-aspartic acid, supplied as a hydrate. This compound is a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise control over stereochemistry and side-chain functionality. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers developing therapeutic peptides, protease inhibitors, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid monomer for the controlled incorporation of aspartic acid into peptide chains.
• Solution-Phase Peptide Synthesis: Used in the synthesis of peptide fragments and small peptides where solution-phase methodologies are preferred.
• Pharmaceutical Intermediates: Serves as a critical intermediate in the production of active pharmaceutical ingredients (APIs) for various drug candidates.
• Protease Inhibitor Development: Employed in the research and synthesis of inhibitors targeting aspartyl proteases due to its aspartic acid backbone.
• Bioconjugation and Labeling: The carboxylic acid group allows for further functionalization, useful in creating labeled peptides or peptide-drug conjugates.
• Academic and R&D: A valuable reagent in university and institutional laboratories for studying peptide structure, function, and novel synthetic methodologies.

Basic Information

Product Name	Z-D-Asp(Otbu)-OH, H2O
CAS No.	210471-09-3
Molecular Formula	C16H21NO6 • xH2O
Molecular Weight	323.34 g/mol (anhydrous basis)
Synonyms	N-Carbobenzoxy-D-aspartic acid β-tert-butyl ester hydrate; Z-D-Aspartic acid β-tert-butyl ester hydrate; (R)-2-((((Benzyloxy)carbonyl)amino)butanedioic acid 4-tert-butyl ester hydrate; Boc-Asp(OtBu)-OH (common error, note Z vs. Boc); Nα-Z-D-Aspartic acid 4-tert-butyl ester; Z-D-Asp(OtBu)-OH monohydrate; Fmoc-Asp(OtBu)-OH (common error, note Z vs. Fmoc); CBZ-D-Asp(OtBu)-OH hydrate
EINECS	Contact for details

Quality Control

Our Z-D-Asp(Otbu)-OH, H2O is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP intermediate applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent hydrolysis of the ester group. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	3.0% - 8.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.