Description

(2S)-2-{[(tert-Butoxycarbonyl)Amino]Methyl}-3-Methylbutanoic Acid is a high-purity, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group on the amine functionality. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for developing active pharmaceutical ingredients (APIs), especially in oncology and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the solid-phase and solution-phase synthesis of novel peptide-based drugs and therapeutic candidates.
• Peptidomimetic Research: Used to incorporate modified, branched-chain amino acid structures into peptidomimetics to enhance metabolic stability and bioavailability.
• API Development: Serves as a crucial building block in the multi-step synthesis of complex target molecules for preclinical and clinical studies.
• Bioconjugation: The carboxylic acid group enables conjugation to other molecules, carriers, or solid supports for creating targeted drug delivery systems.
• Chemical Biology Probes: Employed in the design and synthesis of labeled peptides and activity-based probes for studying enzyme mechanisms and protein-protein interactions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke synthesis services for client-specific molecular entities.

Basic Information

Product Name	(2S)-2-{[(tert-Butoxycarbonyl)Amino]Methyl}-3-Methylbutanoic Acid
CAS No.	210346-16-0
Molecular Formula	C12H23NO4
Molecular Weight	245.32 g/mol
Synonyms	Boc-L-tert-Leucine; (2S)-2-[(tert-Butoxycarbonylamino)methyl]-3-methylbutanoic acid; Boc-Tle-OH; Nα-Boc-L-tert-leucine; Boc-L-tert-butylglycine; (S)-2-((tert-Butoxycarbonylamino)methyl)-3-methylbutanoic acid; N-Boc-3-amino-4-methylpentanoic acid; Boc-Amino(2-methylpropyl)acetic Acid
EINECS	Contact for details

Quality Control

Our (2S)-2-{[(tert-Butoxycarbonyl)Amino]Methyl}-3-Methylbutanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.