Description

Fmoc-L-2-Nitrophenylalanine CAS NO 210282-30-7 is a protected, non-proteinogenic amino acid derivative essential for advanced peptide synthesis. This compound matters as a critical building block for introducing the unique 2-nitrophenylalanine side chain, enabling the study of protein structure, function, and the development of novel bioactive peptides. It is primarily needed by research institutions and pharmaceutical companies engaged in solid-phase peptide synthesis (SPPS), medicinal chemistry, and the development of peptide-based therapeutics and diagnostics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of custom peptides containing the 2-nitrophenylalanine residue.
• Medicinal Chemistry & Drug Discovery: Used to incorporate nitro-aromatic functionalities into peptide backbones for structure-activity relationship (SAR) studies and the creation of novel pharmacophores.
• Biochemical Research: Serves as a precursor for synthesizing peptides used in enzyme studies, receptor binding assays, and probing protein-protein interactions.
• Peptide Library Construction: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Fluorescent Probe Development: The nitro group can serve as a precursor or a quenching moiety in the design of peptide-based fluorescent sensors and probes.
• Material Science: Potential use in creating functionalized surfaces or bio-conjugates where specific peptide sequences are required.

Basic Information

Product Name	Fmoc-L-2-Nitrophenylalanine
CAS No.	210282-30-7
Molecular Formula	C24H20N2O6
Molecular Weight	432.43 g/mol
Synonyms	Fmoc-2-NO2-Phe-OH; Fmoc-L-2-Nitrophenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-nitro-L-phenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(2-nitrophenyl)propanoic acid; Fmoc-2-Nitrophenylalanine; N-Fmoc-2-nitro-L-phenylalanine; Fmoc-2-Nitrophenylalanine-OH; Fmoc-L-Phe(2-NO2)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-L-2-Nitrophenylalanine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing including HPLC, NMR, and MS for identity and purity verification. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.