Description

(S)-(-)-5,5'-Bis[Di(3,5-Xylyl)Phosphino]-4,4'-Bi-1,3-Benzodioxole, Min. 98% (S)-DM-Segphos is a high-purity, chiral bisphosphine ligand essential for achieving exceptional enantioselectivity in asymmetric catalytic reactions. Its value lies in enabling the efficient and cost-effective synthesis of single-enantiomer intermediates for high-value pharmaceuticals and fine chemicals. This ligand is critically needed by R&D scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-performance catalysts.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of dehydroamino acids, enamides, ketones, and imines in API synthesis.
• Pharmaceutical Intermediate Manufacturing: Key catalyst component for producing chiral building blocks for cardiovascular, central nervous system (CNS), and antiviral drugs.
• Cross-Coupling Reactions: Used in asymmetric cross-coupling reactions to form carbon-carbon and carbon-heteroatom bonds with high stereocontrol.
• Agrochemical Synthesis: Enables the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A standard tool in discovery chemistry for investigating new asymmetric transformations and optimizing reaction pathways.
• Process Development & Scale-Up: Provides consistent performance and selectivity for transitioning laboratory-scale reactions to pilot plant and commercial manufacturing.

Basic Information

Item	Details
Product Name	(S)-(-)-5,5'-Bis[Di(3,5-Xylyl)Phosphino]-4,4'-Bi-1,3-Benzodioxole, Min. 98% (S)-DM-Segphos
CAS No.	210169-57-6
Molecular Formula	C52H48O4P2
Molecular Weight	798.88 g/mol
Synonyms	(S)-DM-Segphos; (S)-(-)-DM-Segphos; (S)-5,5'-Bis(di-3,5-xylylphosphino)-4,4'-bi-1,3-benzodioxole; (S)-2,2'-Bis(α,α-dimethylbenzyl)-4,4',6,6'-tetramethylbiphenyl-2,2'-diyl)bis(di-3,5-xylylphosphine); (S)-1,1'-Biphenyl-2,2'-diylbis[(3,5-dimethylphenyl)phenylphosphine] derivative; Segphos Derivative; Chiral DM-Segphos Ligand
EINECS	Contact for details

Quality Control

Every batch of (S)-DM-Segphos is manufactured and tested under strict quality management systems to ensure it meets the high standards required for catalytic applications. We guarantee a minimum purity of 98%, with identity and purity verified by advanced analytical techniques including NMR and HPLC. A comprehensive Certificate of Analysis (COA) detailing chiral purity, chemical purity, and residual solvent levels is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This product is easily oxidized and moisture-sensitive; the original sealed container should be brought to room temperature before opening to minimize condensation and exposure to air.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (NMR)	Conforms to structure
Purity (HPLC)	Min. 98.0%
Chiral Purity (HPLC)	Min. 99.0% ee
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.