Description

(S)-(-)-5,5'-Bis(Diphenylphosphino)-4,4'-Bi-1,3-Benzodioxole, Min. 98% (S)-Segphos is a high-purity, chiral bidentate phosphine ligand widely used in asymmetric catalysis. Its primary value lies in enabling highly enantioselective transformations, which are critical for producing single-isomer pharmaceutical intermediates and fine chemicals. This product is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable and effective chiral auxiliaries for hydrogenation, cross-coupling, and other transition metal-catalyzed reactions.

Application

• As a chiral ligand for asymmetric hydrogenation of olefins, ketones, and imines in pharmaceutical API synthesis.
• Catalyst component for enantioselective cross-coupling reactions (e.g., Suzuki-Miyaura, Heck reactions).
• Key reagent in the production of chiral agrochemicals and fragrance ingredients.
• Used in academic and industrial R&D for developing new catalytic methodologies.
• Facilitates rhodium- and ruthenium-catalyzed asymmetric syntheses with high enantiomeric excess (ee).
• Employed in the synthesis of optically active natural products and complex molecules.

Basic Information

Product Name	(S)-(-)-5,5'-Bis(Diphenylphosphino)-4,4'-Bi-1,3-Benzodioxole, Min. 98% (S)-Segphos
CAS No.	210169-54-3
Molecular Formula	C40H28O4P2
Molecular Weight	634.59 g/mol
Synonyms	(S)-(-)-SegPhos; (S)-Segphos; (S)-5,5'-Bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole; (S)-4,4'-Bi-1,3-benzodioxole-5,5'-diylbis(diphenylphosphine); (S)-2,2'-Dimethyl-4,4',6,6'-tetrakis(diphenylphosphino)-1,1'-biphenyl; (S)-DTMB-SEGPHOS; L-047; (S)-H8-BINAP Analog
EINECS	Contact for details

Quality Control

Our (S)-Segphos is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high enantiopurity. Each lot is analyzed using advanced techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This material is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and efficacy.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 98.0%
Enantiomeric Purity (Chiral HPLC)	Min. 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.