Description

(S)-(+)-5,5'-Bis[Di(3,5-Di-T-Butyl-4-Methoxyphenyl)Phosphino]-4,4'-Bi-1,3-Benzodioxole, Min. 98%, commonly known as (S)-DTBM-SEGPHOS, is a high-performance, chiral bisphosphine ligand essential for asymmetric catalysis. This compound matters because it enables the production of enantiomerically pure intermediates and active pharmaceutical ingredients (APIs) with exceptional selectivity and yield. It is critically needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries for developing efficient and sustainable synthetic routes.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of olefins, ketones, and imines in API synthesis.
• Pharmaceutical Intermediate Manufacturing: Key for producing chiral building blocks for cardiovascular, central nervous system, and antiviral drugs.
• Agrochemical Synthesis: Used in the creation of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Facilitates asymmetric C-C and C-X bond-forming reactions for high-value specialty chemicals.
• Catalyst Screening & Development: A benchmark ligand in R&D for discovering and optimizing new catalytic processes.
• Academic & Industrial Research: Employed in studies of reaction mechanisms and the development of novel catalytic methodologies.

Basic Information

Product Name	(S)-(+)-5,5'-Bis[Di(3,5-Di-T-Butyl-4-Methoxyphenyl)Phosphino]-4,4'-Bi-1,3-Benzodioxole, Min. 98% ((S)-DTBM-SEGPHOS)
CAS No.	210169-40-7
Molecular Formula	C78H96O6P2
Molecular Weight	1191.53 g/mol
Synonyms	(S)-DTBM-SEGPHOS; (S)-5,5'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole; (S)-(-)-DTBM-SEGPHOS (common naming variant); (S)-DTBM-SEGPHOS ligand; (4S,4'S)-4,4'-Bi-1,3-benzodioxole-5,5'-diylbis[bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphine]; SEGPHOS derivative with DTBM substituents; Chiral bisphosphine ligand DTBM-SEGPHOS
EINECS	Contact for details

Quality Control

Our (S)-DTBM-SEGPHOS is manufactured under strict quality management systems to ensure batch-to-batch consistency and high catalytic performance. Every lot undergoes rigorous analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and ICP-MS for trace metal analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Assay (HPLC)	Min. 98.0%
Chiral Purity (HPLC)	Min. 99.0% ee
Loss on Drying	Max. 0.5%
Residue on Ignition	Max. 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.