Description

Cyclocreatine-2-14C CAS NO 210110-93-3 is a carbon-14 labeled isotopologue of cyclocreatine, a synthetic creatine analogue. This radiolabeled compound is an essential tool for metabolic and pharmacokinetic studies, enabling researchers to precisely track the absorption, distribution, metabolism, and excretion (ADME) of cyclocreatine in biological systems. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in neuroscience, oncology, and metabolic disorder research.

Application

• ADME (Absorption, Distribution, Metabolism, Excretion) Studies: Tracing the metabolic fate and pharmacokinetic profile of cyclocreatine in preclinical models.
• Drug Metabolism and Pharmacokinetics (DMPK): Investigating the biotransformation pathways and bioavailability of cyclocreatine-based therapeutic candidates.
• Biochemical Pathway Analysis: Elucidating the role of cyclocreatine in cellular energy metabolism and its interaction with creatine kinase isoforms.
• Neuroprotective Research: Studying the uptake and distribution of cyclocreatine in neural tissues for applications in neurodegenerative diseases and brain injury.
• Oncology Research: Exploring the utilization of cyclocreatine as a potential adjuvant in cancer therapy and its effect on tumor cell energetics.
• Environmental Fate Studies: Monitoring the environmental persistence and breakdown of cyclocreatine-related compounds.
• Reference Standard: Serving as an internal standard for the quantitative analysis of cyclocreatine using advanced techniques like LC-MS.

Basic Information

Product Name	Cyclocreatine-2-14C
CAS No.	210110-93-3
Molecular Formula	C₄H₈¹⁴CN₃O₂
Molecular Weight	~130.11 (based on unlabeled cyclocreatine)
Synonyms	1-Carboxymethyl-2-iminoimidazolidine-2-14C; 2-Imidazolidinone-2-14C, 1-(carboxymethyl)-; Cyclocreatine (2-14C); cCr-2-14C; N-Amidino-N-methylglycine-2-14C cyclic form; 1-Carboxymethyl-2-iminoimidazolidine-2-14C; [2-14C]-Cyclocreatine
EINECS	Contact for details

Quality Control

Every batch of Cyclocreatine-2-14C is manufactured and analyzed under strict quality control protocols to ensure the highest standards of radiochemical purity and chemical identity. Our quality assurance system is designed to meet the rigorous demands of research and regulatory submission. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specific activity, purity by HPLC, radiochemical purity, and solvent content. We support compliance with relevant guidelines for the use of radioactive materials in research.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures (typically 2-8°C or as specified on the label) in a dedicated, properly labeled area for radioactive materials. This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation. Follow all local and institutional regulations for the safe handling and storage of radiochemicals.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98%
Radiochemical Purity	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent Content (Residual Solvents)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.