Description

2,4,5-Trifluorophenylacetic Acid is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the unique reactivity and electronic properties imparted by the specific trifluorophenyl substitution pattern, which is crucial for modulating the biological activity and physicochemical characteristics of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by manufacturers of specialty materials and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and metabolic diseases.
• Agrochemical Synthesis: Used in the development and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance lipophilicity, metabolic stability, and binding affinity.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystal compounds for high-performance displays (LCDs) and optical devices.
• Organic Electronics: Employed in the research and development of organic semiconductors and electro-optical materials due to its electron-withdrawing properties.
• Peptide Mimetics & Bioconjugation: The carboxylic acid functionality allows for coupling reactions to create fluorinated peptide analogs or for use as a linker in bioconjugation chemistry.
• Chemical Research & Development: A valuable reagent for method development, catalysis studies, and exploring new reactions in organofluorine chemistry.

Basic Information

Product Name	2,4,5-Trifluorophenylacetic Acid
CAS No.	209995-38-0
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	(2,4,5-Trifluorophenyl)acetic Acid; 2-(2,4,5-Trifluorophenyl)acetic Acid; α-(2,4,5-Trifluorophenyl)acetic Acid; 2,4,5-Trifluorobenzeneacetic Acid; NSC 405124; 209995-38-0; 2,4,5-Trifluoro-α-toluic Acid
EINECS	Contact for details

Quality Control

Our 2,4,5-Trifluorophenylacetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its nature as a strong acid/organic solvent, handle with appropriate personal protective equipment in a fume hood.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	95 - 100 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.