Description

2-Fluoro-4-(Trifluoromethyl)Phenylacetic Acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring both fluorine and a trifluoromethyl group on the phenylacetic acid backbone, makes it a critical intermediate for creating compounds with enhanced metabolic stability, lipophilicity, and bioavailability. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved activity and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the production of fluorinated liquid crystals for advanced display technologies.
• Organic Electronic Materials: Employed in the synthesis of specialized monomers and polymers for organic light-emitting diodes (OLEDs) and semiconductor applications.
• Chemical Research & Development: A versatile reagent for introducing the 2-fluoro-4-(trifluoromethyl)phenyl moiety into more complex molecular architectures in academic and industrial labs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	2-Fluoro-4-(Trifluoromethyl)Phenylacetic Acid
CAS No.	209991-64-0
Molecular Formula	C9H6F4O2
Molecular Weight	222.14 g/mol
Synonyms	2-Fluoro-α-(trifluoromethyl)phenylacetic Acid; [2-Fluoro-4-(trifluoromethyl)phenyl]acetic Acid; 4-(Trifluoromethyl)-2-fluorophenylacetic Acid; 2-Fluoro-4-trifluoromethylphenylacetic Acid; α-Carboxy-2-fluoro-4-trifluoromethyltoluene; 2-Fluoro-4-(trifluoromethyl)benzeneacetic Acid; F-TFM-PAA (abbrev.)
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-4-(Trifluoromethyl)Phenylacetic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO 9001 guided frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and heat sources. Due to its acidic nature, appropriate chemical handling procedures should be observed.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.