Description

3,4,5-Trifluorophenylacetic Acid is a high-value fluorinated aromatic building block essential for modern synthetic chemistry. This compound serves as a critical intermediate in the development of advanced pharmaceuticals and agrochemicals, where its trifluoromethylphenyl moiety imparts desirable metabolic stability and lipophilicity. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and pesticides, leveraging the fluorine atoms for enhanced biological activity and environmental persistence.
• Liquid Crystal Materials: Used in the production of fluorinated liquid crystals for advanced display technologies.
• Organic Light-Emitting Diodes (OLEDs): Serves as a precursor for electron-transport materials and emissive layer components.
• Polymer Chemistry: Monomer or modifier for introducing fluorinated aromatic units into high-performance polymers.
• Chemical Research & Development: Versatile reagent for medicinal chemistry and material science research, enabling structure-activity relationship (SAR) studies.

Basic Information

Product Name	3,4,5-Trifluorophenylacetic Acid
CAS No.	209991-62-8
Molecular Formula	C8H5F3O2
Molecular Weight	198.12 g/mol
Synonyms	(3,4,5-Trifluorophenyl)acetic Acid; 2-(3,4,5-Trifluorophenyl)acetic Acid; 3,4,5-Trifluorobenzeneacetic Acid; α-(3,4,5-Trifluorophenyl)acetic Acid; NSC 405124; 209991-62-8 (CAS); 3,4,5-Trifluoro-phenyl-acetic acid
EINECS	Contact for details

Quality Control

Our 3,4,5-Trifluorophenylacetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF for moisture content, to ensure it meets the stringent requirements of our global clientele. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	105 - 110 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.