Description

(3R,4R)-1-n-Octyl-3,4-Difluoropyrrolidine CAS NO 209625-78-5 is a high-purity, chiral fluorinated pyrrolidine derivative, a critical building block in advanced organic synthesis. Its value lies in its unique stereochemistry and fluorine atoms, which are essential for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, where the fluorine atoms enhance lipophilicity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Investigated as a monomer or additive for creating specialty polymers with unique surface properties or optical characteristics.
• Fluorine Chemistry Research: An important standard and reagent for studying the effects of stereoselective fluorine introduction in organic molecules.
• Process Chemistry & Scale-up: Supplied for route scouting and optimization studies from milligram to kilogram scale for commercial production pathways.

Basic Information

Product Name	(3R,4R)-1-n-Octyl-3,4-Difluoropyrrolidine
CAS No.	209625-78-5
Molecular Formula	C₁₂H₂₃F₂N
Molecular Weight	219.32 g/mol
Synonyms	(3R,4R)-1-Octyl-3,4-difluoropyrrolidine; 1-Octyl-3,4-difluoropyrrolidine, (3R,4R)-; (3R,4R)-1-n-Octyl-3,4-difluoropyrrolidine; Pyrrolidine, 3,4-difluoro-1-octyl-, (3R,4R)-; 209625-78-5; (3R,4R)-3,4-Difluoro-1-octylpyrrolidine; Fluorinated Chiral Pyrrolidine Derivative
EINECS	Contact for details

Quality Control

Every batch of (3R,4R)-1-n-Octyl-3,4-Difluoropyrrolidine is produced under strict quality management systems. We employ advanced analytical techniques including chiral HPLC, GC, NMR (¹H, ¹³C, ¹⁹F), and mass spectrometry to ensure identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to guarantee traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to strong bases and fluorides, keep away from incompatible materials. The container should be kept tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.