Description

5-Chloro-n-[4-Methoxy-3-(1-Piperazinyl)Phenyl]-3-Methylbenzo[B]Thiophene-2-Sulfonamide Hydrochloride is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound is valued for its role as a key building block in the synthesis of novel therapeutic agents, particularly those targeting complex biochemical pathways. It is primarily required by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of proprietary drug candidates, particularly in oncology and central nervous system (CNS) research.
• Biochemical Research: Used as a reference standard or a tool compound in pharmacological studies to investigate structure-activity relationships (SAR) and receptor binding affinity.
• API Synthesis: Employed in the development and scale-up production of complex sulfonamide-based active pharmaceutical ingredients.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis projects and process development for client-specific molecules.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and medicinal chemistry programs.

Basic Information

Product Name	5-Chloro-n-[4-Methoxy-3-(1-Piperazinyl)Phenyl]-3-Methylbenzo[B]Thiophene-2-Sulfonamide Hydrochloride
CAS No.	209481-24-3
Molecular Formula	C20H21ClN4O3S2 • HCl
Molecular Weight	501.90 g/mol (Free base: 465.00 g/mol)
Synonyms	5-Chloro-3-methyl-N-[4-methoxy-3-(1-piperazinyl)phenyl]-1-benzothiophene-2-sulfonamide hydrochloride; 5-Chloro-3-methyl-N-[4-methoxy-3-(piperazin-1-yl)phenyl]benzo[b]thiophene-2-sulfonamide hydrochloride; 209481-24-3; Benzo[b]thiophene-2-sulfonamide derivative; CAS 209481-24-3.
EINECS	Contact for details

Quality Control

Our 5-Chloro-n-[4-Methoxy-3-(1-Piperazinyl)Phenyl]-3-Methylbenzo[B]Thiophene-2-Sulfonamide Hydrochloride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing comprehensive HPLC purity, related substances, and other critical parameters are provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under inert atmosphere or with desiccant when appropriate to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.