Description

3,5-Difluoro-4-Methoxy-Phenylboronic Acid is a high-purity boronic acid derivative characterized by its distinct difluoro-methoxy substitution pattern. This compound is a critical building block in modern synthetic organic chemistry, particularly valued for its role in facilitating Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by research and development chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds targeting central nervous system and metabolic disorders.
• Agrochemical Synthesis: Used in creating novel herbicides and fungicides, where the difluoro and methoxy groups contribute to biological activity and stability.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research: An essential reagent in academic and industrial R&D for exploring new carbon-carbon bond formation methodologies and catalyst systems.
• Ligand Synthesis: Employed in the preparation of sophisticated ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	3,5-Difluoro-4-Methoxy-Phenylboronic Acid
CAS No.	208641-98-9
Molecular Formula	C7H7BF2O3
Molecular Weight	187.94 g/mol
Synonyms	(3,5-Difluoro-4-methoxyphenyl)boronic acid; 4-Methoxy-3,5-difluorophenylboronic acid; 3,5-Difluoro-4-methoxybenzeneboronic acid; Boronic acid, B-(3,5-difluoro-4-methoxyphenyl)-; 208641-98-9; 3,5-Difluoro-4-methoxybenzeneboronic acid; 3,5-Difluoro-4-methoxy-phenylboronic acid
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-Methoxy-Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive coupling reactions. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.