Description

Granulocyte Colony-Stimulating Factor Precursor is a critical intermediate in the biopharmaceutical synthesis of recombinant human G-CSF, a vital hematopoietic growth factor. This high-purity precursor is essential for ensuring the final biologic's efficacy, safety, and batch-to-batch consistency in therapeutic manufacturing. It is primarily required by biopharmaceutical companies and advanced research institutions engaged in the development and production of oncology supportive care drugs, treatments for neutropenia, and other immunotherapies.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Key starting material for the production of recombinant human Granulocyte Colony-Stimulating Factor (rhG-CSF).
• Oncology Supportive Care: Used in manufacturing drugs that stimulate white blood cell production following chemotherapy.
• Biopharmaceutical Research & Development: Serves as a critical reference standard and intermediate in the development of biosimilars and novel biologic entities.
• Treatment of Severe Chronic Neutropenia: Integral to producing therapies for patients with congenital, cyclic, or idiopathic neutropenia.
• Stem Cell Mobilization: Used in the production of agents that mobilize hematopoietic stem cells from bone marrow to peripheral blood for collection and transplant.
• Process Development & Scale-Up: Employed in optimizing fermentation, purification, and refolding processes for commercial-scale G-CSF production.

Basic Information

Item	Detail
Product Name	Granulocyte Colony-Stimulating Factor Precursor
CAS No.	208265-92-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	G-CSF Precursor; Recombinant Human G-CSF Precursor; Filgrastim Precursor; Lenograstim Precursor; Granulocyte Colony-Stimulating Factor (1-174) (human); Granulocyte Colony-Stimulating Factor (human); Plerixafor Intermediate (related); Hematopoietic Growth Factor Precursor
EINECS	Contact for details

Quality Control

Our Granulocyte Colony-Stimulating Factor Precursor is manufactured under strict quality systems designed for pharmaceutical intermediates. Each batch is subjected to rigorous analytical testing, including advanced chromatographic and spectroscopic methods, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment aligns with ICH guidelines and supports our customers' needs for GMP-compliant sourcing.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature or as specified on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment. For long-term storage, consider conditions of 2-8°C. Handle under aseptic conditions appropriate for a pharmaceutical intermediate.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Proteins (HPLC)	≤ 5.0% total
Water Content (KF)	≤ 5.0%
Biological Activity	Assessed by cell-based assay (upon request)
Endotoxin (LAL)	< 10 EU/mg
Sterility (Membrane Filtration)	Sterile or Low Bioburden (Grade specific)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.