Description

Fmoc-(R)-2-Thienylglycine is a high-purity, non-natural amino acid derivative featuring a thiophene side chain, protected at the N-terminus with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is essential for the solid-phase peptide synthesis (SPPS) of peptides requiring specific stereochemistry and enhanced structural diversity or unique electronic properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the Fmoc-strategy synthesis of complex peptides, enabling the incorporation of a chiral, non-natural amino acid with a heterocyclic side chain.
• Pharmaceutical Research: Used in the discovery and development of peptide drugs, where the thienylglycine moiety can influence bioavailability, receptor binding affinity, and metabolic stability.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or peptide-based imaging agents and diagnostic probes.
• Chemical Biology Studies: Employed to investigate protein-protein interactions, enzyme specificity, and to create peptide libraries for screening.
• Material Science: Potential use in the synthesis of peptidomimetics and functional organic materials that leverage the electronic characteristics of the thiophene ring.

Basic Information

Product Name	Fmoc-(R)-2-Thienylglycine
CAS No.	208259-66-9
Molecular Formula	C₂₂H₁₉NO₄S
Molecular Weight	393.45 g/mol
Synonyms	Fmoc-(R)-2-Thienylglycine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2-thienyl)-D-alanine; Fmoc-D-2-Thienylglycine; N-Fmoc-3-(2-thienyl)-D-alanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(thiophen-2-yl)acetic acid; Fmoc-Thg-OH; Fmoc-D-Thg-OH; N-α-Fmoc-3-(2-thienyl)-D-alanine
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-2-Thienylglycine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.