Description

(R)-(+)-2,2'-Bis(n-Diphenylphosphinoamino)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthyl CAS NO 208248-67-3 is a high-value, chiral bisphosphine ligand derived from the H8-BINAP scaffold, where the phosphorus atoms are functionalized with diphenylphosphinoamino groups. This compound matters for its exceptional ability to induce high enantioselectivity in transition metal-catalyzed asymmetric reactions, a critical requirement for producing single-enantiomer pharmaceuticals and fine chemicals. It is primarily needed by research and development chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of prochiral olefins, ketones, and imines, crucial for synthesizing chiral active pharmaceutical ingredients (APIs).
• Asymmetric C-C Bond Formation: Employed in cross-coupling reactions, allylic alkylations, and other C-C bond-forming processes to construct complex chiral molecules.
• Catalyst Screening & Development: A key component in catalyst libraries for high-throughput screening (HTS) to discover new asymmetric transformations.
• Process Chemistry Optimization: Used to scale up and optimize catalytic steps in the commercial manufacturing of enantiopure compounds.
• Academic & Industrial Research: A valuable tool for investigating new mechanistic pathways and developing novel catalytic methodologies in synthetic chemistry.

Basic Information

Product Name	(R)-(+)-2,2'-Bis(n-Diphenylphosphinoamino)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthyl
CAS No.	208248-67-3
Molecular Formula	C52H48N2P2
Molecular Weight	762.90 g/mol
Synonyms	(R)-H8-BINAP(NHPh)2; (R)-(+)-H8-BINAP-DPPA; (R)-2,2'-Bis(diphenylphosphinoamino)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl; (R)-Octahydro-BINAP-DPPA; (R)-H8-BINAP-Diphenylphosphinoamide; (R)-DPPA-H8-BINAP; (R)-1,1'-Binaphthalene-2,2'-diylbis[N-(diphenylphosphanyl)amine] (octahydro derivative)
EINECS	Contact for details

Quality Control

Our (R)-(+)-2,2'-Bis(n-Diphenylphosphinoamino)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthyl is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification and 31P/1H NMR for structural confirmation and purity assessment. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized; ensure containers are sealed immediately after use to minimize exposure to air.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (HPLC)	≥ 99.0% ee
31P NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.