Description

4-(tert-Butyl)-N-methoxy-N-methylbenzamide is a specialized organic compound belonging to the class of Weinreb amides, which are pivotal synthetic intermediates in modern organic chemistry. Its primary value lies in its role as a highly effective acylating agent, enabling the controlled synthesis of ketones from organometallic reagents such as Grignard or organolithium compounds. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for complex molecule synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing ketone moieties in drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where specific benzamide derivatives are required.
• Organic Synthesis & Research: Serves as a versatile Weinreb amide reagent for academic and industrial R&D laboratories exploring new chemical entities and reaction pathways.
• Material Science Precursor: Employed in the synthesis of specialty polymers and liquid crystals that incorporate tert-butyl and benzamide functional groups.
• Fine Chemical Production: Integral to the multi-step synthesis of complex fragrance and flavor compounds.

Basic Information

Product Name	4-(tert-Butyl)-N-methoxy-N-methylbenzamide
CAS No.	208188-23-2
Molecular Formula	C14H21NO2
Molecular Weight	235.32 g/mol
Synonyms	N-Methoxy-N-methyl-4-tert-butylbenzamide; 4-tert-Butyl-N-methoxy-N-methylbenzamide; p-tert-Butyl-N-methoxy-N-methylbenzamide; Benzamide, N-methoxy-N-methyl-4-(1,1-dimethylethyl)-; 4-(1,1-Dimethylethyl)-N-methoxy-N-methylbenzamide; Weinreb amide of 4-tert-Butylbenzoic acid
EINECS	Contact for details

Quality Control

Every batch of 4-(tert-Butyl)-N-methoxy-N-methylbenzamide is produced under strict quality management protocols. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, NMR, and GC, is performed to verify identity, purity, and consistency. A Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.