Description

2'-Fluoro-4'-(trifluoromethyl)propiophenone is a high-value fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethyl substituents, makes it a critical intermediate for developing compounds with enhanced metabolic stability and lipophilicity. This product is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and anti-inflammatory agents.
• Agrochemical Research: Used in the synthesis of novel herbicides and pesticides, where the fluorine atoms contribute to improved biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, enhancing charge transport and stability.
• Advanced Organic Synthesis: Employed in cross-coupling reactions, carbonyl chemistry, and as a precursor for chiral ligands and catalysts.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research into the effects of fluorination on molecular properties.

Basic Information

Product Name	2'-Fluoro-4'-(trifluoromethyl)propiophenone
CAS No.	208173-16-4
Molecular Formula	C10H8F4O
Molecular Weight	220.16 g/mol
Synonyms	1-(2-Fluoro-4-(trifluoromethyl)phenyl)propan-1-one; 2-Fluoro-4-(trifluoromethyl)propiophenone; 1-Propanone, 1-[2-fluoro-4-(trifluoromethyl)phenyl]-; 2'-Fluoro-α,α,α-trifluoro-4-propiophenone; 2-Fluoro-α,α,α-trifluoro-p-propiophenone; 2-Fluoro-4-trifluoromethylpropiophenone; 208173-16-4
EINECS	Contact for details

Quality Control

We maintain rigorous quality control protocols for all our fluorinated intermediates. Production follows strict internal specifications, and each batch is analyzed to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity (typically >97% by HPLC), physical characteristics, and impurity profiles is provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.