Description

Temozolomide-D3 CAS NO 208107-14-6 is a deuterated analog of the alkylating chemotherapeutic agent temozolomide, specifically labeled with three deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in the development and analysis of oncology therapeutics.

Application

• Internal Standard for LC-MS/MS: Primary application as a deuterated internal standard for the precise quantification of temozolomide in biological matrices (plasma, serum, tissue homogenates) using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate studies on the absorption, distribution, metabolism, and excretion (ADME) profile of temozolomide in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Serves as a critical reference material for developing, validating, and ensuring the regulatory compliance of analytical methods according to FDA and ICH guidelines.
• Clinical Trial Support: Used in the bioanalysis of patient samples during clinical trials for glioblastoma multiforme and other malignancies to monitor drug exposure and efficacy.
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex biological samples.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in in-process testing and stability studies for temozolomide-based drug products.

Basic Information

Product Name	Temozolomide-D3
CAS No.	208107-14-6
Molecular Formula	C6H3D3N6O2
Molecular Weight	198.19 g/mol
Synonyms	3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide-d3; 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one-d3; Temozolomide (methyl-d3); Temodal-d3; Temodar-d3; TMZ-d3; NSC 362856-d3
EINECS	Contact for details

Quality Control

Our Temozolomide-D3 is manufactured under strict quality systems to ensure it meets the exacting requirements for use as a certified reference material. Each batch undergoes comprehensive analytical testing, including HPLC for chemical and isotopic purity, NMR for structural confirmation and deuterium incorporation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided, documenting batch-specific data. Our quality commitment aligns with the standards expected for materials used in GLP and GMP-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Incorporation)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.