Description

n-(5-Bromo-Pyridin-2-Yl)-2,2,2-Trifluoro-Acetamide is a high-purity, specialized organic intermediate featuring a brominated pyridine core and a trifluoroacetamide functional group. This compound is valued for its role as a critical building block in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and novel materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, leveraging the biological activity of the halogenated pyridine moiety.
• Ligand and Catalyst Development: Serves as a starting material for creating novel ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as charge-transport layers or photoactive components, due to its electron-deficient aromatic system.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions for clinical trial materials.
• Academic and Industrial R&D: Utilized in discovery chemistry for structure-activity relationship (SAR) studies and library synthesis in medicinal chemistry programs.

Basic Information

Product Name	n-(5-Bromo-Pyridin-2-Yl)-2,2,2-Trifluoro-Acetamide
CAS No.	207926-35-0
Molecular Formula	C7H4BrF3N2O
Molecular Weight	269.02 g/mol
Synonyms	2,2,2-Trifluoro-N-(5-bromopyridin-2-yl)acetamide; N-(5-Bromo-2-pyridinyl)-2,2,2-trifluoroacetamide; 5-Bromo-2-pyridinyltrifluoroacetamide; 2,2,2-Trifluoroacetamide, N-(5-bromo-2-pyridinyl)-; 5-Bromo-2-trifluoroacetamidopyridine; 2-Acetamido-5-bromopyridine, 2,2,2-trifluoro-; 207926-35-0; 5-Bromo-2-pyridyltrifluoroacetamide
EINECS	Contact for details

Quality Control

Our n-(5-Bromo-Pyridin-2-Yl)-2,2,2-Trifluoro-Acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.