Description

2,5-Difluoromandelic Acid is a fluorinated mandelic acid derivative, a versatile chiral building block and intermediate in advanced organic synthesis. Its value lies in the introduction of fluorine atoms, which can significantly alter the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is particularly essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), potentially for central nervous system (CNS) drugs, anti-inflammatory agents, and other therapeutic molecules.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and pesticides where fluorine substitution enhances efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of specialty monomers for advanced polymers and liquid crystals, leveraging the unique electronic properties of fluorine.
• Chemical Biology & Proteomics: Acts as a building block for activity-based probes and other tools used to study enzyme function and biological pathways.

Basic Information

Product Name	2,5-Difluoromandelic Acid
CAS No.	207853-61-0
Molecular Formula	C8H6F2O3
Molecular Weight	188.13 g/mol
Synonyms	2,5-Difluoro-α-hydroxybenzeneacetic acid; (2,5-Difluorophenyl)(hydroxy)acetic acid; DL-2,5-Difluoromandelic Acid; (±)-2,5-Difluoromandelic Acid; α-Hydroxy-2,5-difluorophenylacetic acid; Mandelic acid, 2,5-difluoro-; 2,5-Difluorophenylglycolic acid
EINECS	Contact for details

Quality Control

Our 2,5-Difluoromandelic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.