Description

Thrombin (B 147-158) (Human) is a synthetic peptide fragment corresponding to a specific sequence of the human thrombin B chain. This high-purity biochemical is critical for advanced research into hemostasis, thrombosis, and related signaling pathways. It serves as a vital tool for pharmaceutical R&D, diagnostic assay development, and academic studies in cardiovascular biology and coagulation science. CAS No. 207553-42-2.

Application

• Biochemical Research: Used as a specific substrate or inhibitor in enzymatic studies to investigate thrombin's structure, function, and interaction with other proteins.
• Pharmaceutical Development: Employed in screening assays and mechanism-of-action studies for the discovery of novel anticoagulant and procoagulant therapeutics.
• Diagnostic Reagent Component: Incorporated into in vitro diagnostic kits for the quantitative or qualitative measurement of thrombin activity or related coagulation factors.
• Cell Signaling Studies: Applied in cellular models to study protease-activated receptor (PAR) signaling pathways activated by thrombin.
• Standard Reference Material: Serves as a calibrated standard in analytical methods such as HPLC or mass spectrometry for quality control of related products.

Basic Information

Product Name	Thrombin (B 147-158) (Human)
CAS No.	207553-42-2
Molecular Formula	C68H111N21O19S2
Molecular Weight	1562.9 g/mol
Synonyms	Thrombin Receptor Agonist Peptide (TRAP-6); SFLLRN; H-Ser-Phe-Leu-Leu-Arg-Asn-OH; SFLLRN-NH2; PAR-1 Activating Peptide; Thrombin Receptor (42-47) (Human); Thrombin Receptor (1-6) (Human); PAR1 Agonist Peptide
EINECS	Contact for details

Quality Control

Our Thrombin (B 147-158) (Human) is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided to ensure the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.