Description

3-[(E)-(3-Fluorophenyl)Methylidene]-2,3-Dihydro-4H-Chromen-4-One is a high-purity, synthetic chromenone derivative, recognized for its role as a key intermediate in advanced organic synthesis. This compound matters for its structural framework, which is integral to developing novel molecules with potential biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, agrochemical research, and the development of new functional materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory pathways.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, leveraging its fluorinated aromatic structure for enhanced bioactivity and environmental stability.
• Material Science: Acts as a precursor for organic light-emitting diodes (OLEDs) and other advanced electronic materials due to its conjugated chromenone core.
• Academic & R&D: Employed in university and corporate laboratories for methodological studies in organic chemistry, including cross-coupling and cyclization reactions.
• Chemical Synthesis: Functions as a versatile synthon for creating complex heterocyclic compounds and fluorinated analogs for structure-activity relationship (SAR) studies.

Basic Information

Product Name	3-[(E)-(3-Fluorophenyl)Methylidene]-2,3-Dihydro-4H-Chromen-4-One
CAS No.	207442-39-5
Molecular Formula	C₁₆H₁₁FO₂
Molecular Weight	254.26 g/mol
Synonyms	(E)-3-(3-Fluorobenzylidene)chroman-4-one; 3-[(E)-3-Fluorobenzylidene]-4-chromanone; 3-(3-Fluorobenzylidene)chroman-4-one; 4H-1-Benzopyran-4-one, 3-[(E)-(3-fluorophenyl)methylene]-2,3-dihydro-; 3-(3-Fluorobenzylidene)-2,3-dihydro-4H-chromen-4-one; 3-(3-Fluorobenzylidene)-4-chromanone; 3-(3-Fluorobenzylidene)chromone; 3-(3-Fluorobenzylidene)-4H-chromen-4-one
EINECS	Contact for details

Quality Control

Our 3-[(E)-(3-Fluorophenyl)Methylidene]-2,3-Dihydro-4H-Chromen-4-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to light and propensity for oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.