Description

(R,S)-n-Fmoc-N'-Boc-Imidazolidine-2-Carboxylic Acid is a protected amino acid derivative, specifically an imidazolidine carboxylic acid, designed for advanced peptide synthesis and medicinal chemistry research. This compound is a critical building block for the introduction of constrained, cyclic structures into peptide chains, which can enhance metabolic stability and biological activity. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on developing novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc/Boc-protected intermediate for the controlled incorporation of imidazolidine motifs into peptide sequences.
• Peptidomimetic Drug Discovery: Used to create conformationally restricted peptide analogs to improve drug-like properties such as bioavailability and receptor selectivity.
• Combinatorial Chemistry Libraries: A valuable scaffold for generating diverse libraries of cyclic peptide-like compounds for high-throughput screening.
• Protease Inhibitor Development: The imidazolidine core can mimic transition states, making it useful in designing inhibitors for various proteolytic enzymes.
• Chemical Biology Probes: Employed in the synthesis of tagged or labeled peptides for studying protein-protein interactions and cellular processes.
• Academic Research: Fundamental studies in organic synthesis, heterocyclic chemistry, and the development of new peptide coupling methodologies.

Basic Information

Product Name	(R,S)-n-Fmoc-N'-Boc-Imidazolidine-2-Carboxylic Acid
CAS No.	207129-12-2
Molecular Formula	C24H26N2O6
Molecular Weight	438.47 g/mol
Synonyms	Fmoc-N-Boc-imidazolidine-2-carboxylic acid; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-1-[(1,1-dimethylethoxy)carbonyl]imidazolidine-4-carboxylic acid; (Rac)-Nα-Fmoc-Nim-Boc-imidazolidine-2-carboxylic acid; 1-N-Boc-2-N-Fmoc-imidazolidine-4-carboxylic acid; Nα-Fmoc-Nim-Boc-2,4-imidazolidinedicarboxylic acid derivative; Protected imidazolidine diacid; Boc-Fmoc-Imd-COOH.
EINECS	Contact for details

Quality Control

Our (R,S)-n-Fmoc-N'-Boc-Imidazolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the container to reach room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.