Description

(2S)-2-Amino-3,3-Dimethyl-n-(Phenylmethyl)-Butanamide is a high-purity, non-natural amino acid derivative characterized by its chiral center and sterically hindered structure. This compound is a critical pharmaceutical intermediate and building block for the synthesis of complex bioactive molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for developing new therapeutic agents, including protease inhibitors and other peptidomimetics.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting viral proteases and other enzymes.
• Peptidomimetic Research: Used in medicinal chemistry to design and synthesize peptide analogs with enhanced metabolic stability and bioavailability.
• Protease Inhibitor Development: Serves as a core structural component for creating inhibitors of serine, cysteine, or aspartic proteases.
• Chemical Biology & Drug Discovery: Employed in library synthesis for high-throughput screening to identify novel lead compounds.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized fine chemicals for clients.
• Academic Research: Used in university and institutional labs for studying enzyme mechanisms, structure-activity relationships (SAR), and asymmetric synthesis methodologies.

Basic Information

Product Name	(2S)-2-Amino-3,3-Dimethyl-n-(Phenylmethyl)-Butanamide
CAS No.	207121-91-3
Molecular Formula	C13H20N2O
Molecular Weight	220.31 g/mol
Synonyms	L-tert-Leucine benzylamide; (S)-2-Amino-3,3-dimethyl-N-benzylbutanamide; N-Benzyl-L-tert-leucinamide; (2S)-2-Amino-3,3-dimethyl-N-(phenylmethyl)butanamide; (S)-2-Amino-N-benzyl-3,3-dimethylbutanamide; tert-Leucine benzylamide; L-tert-Leu-NH-Bn; Bn-L-tert-Leu-NH2
EINECS	Contact for details

Quality Control

Our (2S)-2-Amino-3,3-Dimethyl-n-(Phenylmethyl)-Butanamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric excess, meeting the stringent requirements for pharmaceutical R&D and cGMP applications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.