Description

4-Fluoro-2-(Trifluoromethyl)Benzyl Bromide is a high-value, multi-functional benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both fluorine and trifluoromethyl groups, makes it an essential reagent for introducing specific fluorinated motifs into target molecules, which is crucial for modulating their physical, chemical, and biological properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by material scientists developing specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in creating molecules with enhanced metabolic stability, bioavailability, and membrane permeability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorinated aromatic ring contributes to efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance displays (LCDs) due to its ability to influence dielectric anisotropy and viscosity.
• Polymer Modification: Employed to introduce fluorinated benzyl groups into polymer backbones or side chains, enhancing material properties like chemical resistance, thermal stability, and surface characteristics.
• Organic Electronics: Acts as a building block for electron-transport materials, semiconductors, and other components in OLEDs and organic photovoltaics.
• Cross-Coupling Reactions: Functions as a versatile electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing complex biaryl systems.
• Chemical Research & Development: A valuable tool for medicinal chemists and synthetic organic chemists exploring structure-activity relationships (SAR) and novel synthetic pathways.

Basic Information

Item	Details
Product Name	4-Fluoro-2-(Trifluoromethyl)Benzyl Bromide
CAS No.	206860-48-2
Molecular Formula	C9H5BrF4
Molecular Weight	261.04 g/mol
Synonyms	α-Bromo-4-fluoro-α,α,α-trifluoro-o-xylene; 1-(Bromomethyl)-4-fluoro-2-(trifluoromethyl)benzene; 4-Fluoro-α-(bromomethyl)-α,α,α-trifluoro-o-xylene; (4-Fluoro-2-(trifluoromethyl)phenyl)methyl bromide; 2-(Trifluoromethyl)-4-fluorobenzyl bromide; 4-Fluoro-2-trifluoromethylbenzyl bromide
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-(Trifluoromethyl)Benzyl Bromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes data from techniques such as HPLC, GC, NMR, and IR spectroscopy to confirm identity, purity, and the absence of critical impurities. Our quality commitment ensures reliable performance and batch-to-batch consistency for your R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.