Description

D-Phenylalanine, 3,3-Dibromo-3-Chloro-n-[(1R)-2-Methoxy-2-Oxo-1-(Phenylmethyl)Ethyl]Alanyl-, Methyl Ester (9Ci) is a complex, stereochemically defined synthetic amino acid derivative, serving as a critical chiral building block and advanced intermediate in sophisticated organic synthesis. Its precise molecular architecture, featuring multiple halogen substituents and a protected ester group, makes it invaluable for constructing peptide mimetics and biologically active compounds with high specificity. This high-purity intermediate is primarily targeted at research institutions and pharmaceutical development teams focused on medicinal chemistry, process R&D, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for peptide-based drugs and enzyme inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the biological activity of new chemical entities.
• Process Chemistry: Serves as a defined starting material or intermediate in the scale-up and optimization of synthetic routes for complex molecules.
• Peptidomimetic Synthesis: Employed in the construction of peptide analogs and mimetics designed for enhanced stability, bioavailability, or receptor selectivity.
• Chemical Biology Probes: Utilized in the synthesis of labeled or tagged compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific advanced intermediates.

Basic Information

Product Name	D-Phenylalanine, 3,3-Dibromo-3-Chloro-n-[(1R)-2-Methoxy-2-Oxo-1-(Phenylmethyl)Ethyl]Alanyl-, Methyl Ester (9Ci)
CAS No.	206748-72-3
Molecular Formula	C22H23Br2ClN2O5
Molecular Weight	590.69 g/mol
Synonyms	Methyl (2R)-2-[(2S)-2-[(2R)-2-Amino-3,3-dibromo-3-chloro-2-phenylpropanamido]-3-phenylpropanamido]-3-phenylpropanoate; L-Phenylalanine, N-[(1R)-2-methoxy-2-oxo-1-(phenylmethyl)ethyl]-3,3-dibromo-3-chloro-D-alanyl-, methyl ester; Methyl N-[(1R)-2-methoxy-2-oxo-1-benzylethyl]-3,3-dibromo-3-chloro-D-alanyl-D-phenylalaninate; A complex halogenated dipeptide ester derivative. (Additional systematic names available on request).
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and analyzed under strict quality management protocols to ensure exceptional purity and batch-to-batch consistency, critical for research and development applications. Our quality assurance includes comprehensive analytical characterization using techniques such as HPLC, NMR, and MS to confirm identity, purity, and chiral integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.