Description

4-Chloro-3-Fluorobenzyl Bromide is a versatile and highly reactive halogenated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to introduce the 4-chloro-3-fluorobenzyl moiety, a key structural motif for modulating the biological activity and physicochemical properties of target molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, where it is used to develop new active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and pesticides, where the halogenated benzyl group can enhance bioactivity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Cross-Coupling Reactions: An effective electrophile in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Functional Material Research: Employed in the development of advanced polymers, ligands for catalysis, and other specialty chemicals requiring a halogenated benzyl group.

Basic Information

Product Name	4-Chloro-3-Fluorobenzyl Bromide
CAS No.	206362-80-3
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	1-(Bromomethyl)-4-chloro-3-fluorobenzene; (4-Chloro-3-fluorophenyl)methyl bromide; 4-Chloro-3-fluorobenzyl bromide; 4-Chloro-3-fluoro-α-bromotoluene; 4-Chloro-3-fluorobenzylbromide; 4-Chloro-3-fluoro-benzylbromide; α-Bromo-4-chloro-3-fluorotoluene; 206362-80-3
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Fluorobenzyl Bromide is produced under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. We provide full traceability and a detailed Certificate of Analysis (COA) with each shipment, guaranteeing compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.