Description

2,2-Difluoro-2-(4-Nitrophenyl)Acetic Acid is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both difluoroacetic and nitrophenyl moieties, makes it a valuable precursor for creating complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing difluoroacetic acid derivatives into bioactive molecules.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and pesticides where the fluorinated aromatic core can enhance biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of monomers for specialty polymers and advanced materials with specific optical or electronic properties.
• Chemical Biology Probes: Useful for constructing molecular probes and tags used in biochemical and diagnostic research due to its reactive handles.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the fine chemical market.

Basic Information

Product Name	2,2-Difluoro-2-(4-Nitrophenyl)Acetic Acid
CAS No.	206360-56-7
Molecular Formula	C8H5F2NO4
Molecular Weight	217.13 g/mol
Synonyms	4-Nitro-α,α-difluorophenylacetic Acid; (4-Nitrophenyl)difluoroacetic Acid; 2,2-Difluoro-2-(4-nitrophenyl)ethanoic Acid; α,α-Difluoro-4-nitrobenzeneacetic Acid; 2-(4-Nitrophenyl)-2,2-difluoroacetic Acid; Difluoro(4-nitrophenyl)acetic Acid; p-Nitrophenyldifluoroacetic Acid
EINECS	Contact for details

Quality Control

Every batch of 2,2-Difluoro-2-(4-Nitrophenyl)Acetic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles. Our quality commitment supports compliance with ISO and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.