Description

(R)-3-Bromo-n-(4-Cyano-3-Trifluoromethylphenyl)-2-Hydroxy-2-Methylpropionamide CAS NO 206193-17-1 is a high-purity, chiral small molecule building block of significant interest in advanced pharmaceutical research and development. Its value lies in its complex molecular architecture, featuring a trifluoromethyl group, a cyano substituent, and a brominated hydroxy amide core, which makes it a versatile intermediate for constructing bioactive compounds. This product is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly non-steroidal compounds targeting specific hormonal pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly in oncology and endocrinology.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the synthetic route for non-steroidal selective receptor modulators and other high-value APIs.
• Agrochemical Research: Serves as a building block for developing new generation pesticides and herbicides with optimized activity profiles.
• Chemical Biology & Probe Development: Utilized in the creation of molecular probes to study biological pathways and protein-ligand interactions.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale manufacturing of complex molecules.
• Custom Synthesis & Contract Manufacturing: A critical starting material for fine chemical suppliers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	(R)-3-Bromo-n-(4-Cyano-3-Trifluoromethylphenyl)-2-Hydroxy-2-Methylpropionamide
CAS No.	206193-17-1
Molecular Formula	C₁₂H₁₀BrF₃N₂O₂
Molecular Weight	351.12 g/mol
Synonyms	(R)-3-Bromo-2-hydroxy-2-methyl-N-[4-cyano-3-(trifluoromethyl)phenyl]propanamide; Bicalutamide Impurity; (R)-Bicalutamide Related Compound; (R)-Enantiomer of 3-Bromo-N-(4-cyano-3-trifluoromethylphenyl)-2-hydroxy-2-methylpropionamide; (R)-3-Bromo-2-hydroxy-2-methyl-1-oxo-N-[4-cyano-3-(trifluoromethyl)phenyl]-1-propanamine; Bicalutamide EP Impurity C; CAS 206193-17-1
EINECS	Contact for details

Quality Control

Our (R)-3-Bromo-n-(4-Cyano-3-Trifluoromethylphenyl)-2-Hydroxy-2-Methylpropionamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by spectroscopic methods. We provide comprehensive Certificates of Analysis (COA) detailing purity, impurities, and physical parameters, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (R)-Isomer
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.