Description

Fmoc-L-3-Nitrophenylalanine is a protected, non-natural amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is specifically engineered for the controlled introduction of the 3-nitrophenylalanine residue, a valuable building block for creating peptides with unique electronic and structural properties. It is a critical raw material for researchers and manufacturers in pharmaceutical R&D, biotechnology, and advanced materials science who require high-purity, specialty amino acids for novel peptide-based therapeutics and probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary building block for the incorporation of 3-nitrophenylalanine into custom peptide sequences.
• Pharmaceutical Research: Synthesis of peptide drug candidates, enzyme inhibitors, and receptor ligands where the nitro group serves as a spectroscopic probe, electron acceptor, or precursor for further chemical modification.
• Bioconjugation & Probe Development: Used to create labeled peptides for fluorescence quenching studies, photoaffinity labeling, or as intermediates for attaching other functional groups.
• Material Science: Incorporation into peptidomimetics and bio-inspired polymers to impart specific electronic or self-assembly characteristics.
• Academic & Industrial R&D: Fundamental research tool in organic chemistry, biochemistry, and medicinal chemistry for exploring protein structure-function relationships.

Basic Information

Product Name	Fmoc-L-3-Nitrophenylalanine
CAS No.	206060-42-6
Molecular Formula	C24H20N2O6
Molecular Weight	432.43 g/mol
Synonyms	Fmoc-3-Nitro-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-nitro-L-phenylalanine; Fmoc-L-Phe(3-NO2)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(3-nitrophenyl)propanoic acid; N-α-Fmoc-3-nitrophenylalanine; Fmoc-3-nitrophenylalanine; Fmoc-Phe(3-NO2)-OH; L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-nitro-
EINECS	Contact for details

Quality Control

Our Fmoc-L-3-Nitrophenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation	-15° to -25° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.